Surgical Management of Pancreatic Neuroendocrine Tumors

Tanaz Vaghaiwalla; Xavier M Keutgen

doi:10.1016/j.soc.2019.11.008

Surgical Management of Pancreatic Neuroendocrine Tumors

Surg Oncol Clin N Am. 2020 Apr;29(2):243-252. doi: 10.1016/j.soc.2019.11.008.

Authors

Tanaz Vaghaiwalla¹, Xavier M Keutgen²

Affiliations

¹ Department of Surgery, Division of General Surgery and Surgical Oncology, Endocrine Research Program, University of Chicago Medicine, 5841 South Maryland Avenue, MC4052, Chicago, IL 60637, USA.
² Department of Surgery, Division of General Surgery and Surgical Oncology, Endocrine Research Program, University of Chicago Medicine, 5841 South Maryland Avenue, MC4052, Chicago, IL 60637, USA. Electronic address: xkeutgen@surgery.bsd.uchicago.edu.

PMID: 32151358
DOI: 10.1016/j.soc.2019.11.008

Abstract

Surgical management of pancreatic neuroendocrine tumors (PNETS) is steadily evolving and is influenced by multiple factors. Sporadic PNETs are generally managed more aggressively than those occurring in the background of hereditary syndromes, and functioning PNETs are almost always resected if they are not metastatic. Localized nonfunctioning PNETs less than 2 cm can often be observed. Surgical resection for localized PNET greater than 2 cm comprises parenchymal sparing pancreas resections, such as enucleations, or formal anatomic resection, such as distal pancreatectomy or pancreaticoduodenectomy. PNETs commonly metastasize to the liver, and several systemic and liver-directed options to treat hepatic metastases are available.

Keywords: Hepatic metastases; Liver debulking surgery; Pancreatic neuroendocrine tumor; Primary tumor resection.

Publication types

Review

MeSH terms

Animals
Humans
Neuroendocrine Tumors / pathology
Neuroendocrine Tumors / surgery*
Pancreatectomy / methods*
Pancreatic Neoplasms / pathology
Pancreatic Neoplasms / surgery*
Pancreaticoduodenectomy / methods*