Management of Other Gastric and Duodenal Neuroendocrine Tumors

Surg Oncol Clin N Am. 2020 Apr;29(2):253-266. doi: 10.1016/j.soc.2019.11.009.


Gastric and duodenal neuroendocrine tumors (NETs) are increasing in incidence as a result of increased detection and awareness of neuroendocrine tumors as distinct tumor types. The three types of gastric NETs and duodenal NETs have different etiologies and tumor-specific factors, such as grade, location, and hormone-production, and the clinical settings influence management. Options for treatment include removal by local endoscopic resection and surgical resection. Medical therapy is used to treat the inciting condition or as systemic therapy in advanced disease. Although the overall prognosis for most is good, higher grade tumors behave aggressively and have reduced survival.

Keywords: Carcinoid tumor; Duodenal neuroendocrine tumor; Gastric neuroendocrine tumor; Neuroendocrine; Zollinger-Ellison syndrome.

Publication types

  • Review

MeSH terms

  • Animals
  • Disease Management
  • Duodenal Neoplasms / pathology
  • Duodenal Neoplasms / therapy*
  • Humans
  • Neuroendocrine Tumors / pathology
  • Neuroendocrine Tumors / therapy*
  • Stomach Neoplasms / pathology
  • Stomach Neoplasms / therapy*