Blood pressure variability and outcome after acute intracerebral hemorrhage

J Neurol Sci. 2020 Jun 15;413:116766. doi: 10.1016/j.jns.2020.116766. Epub 2020 Mar 2.


Intracerebral hemorrhage (ICH) is life threatening neurologic event that results in significant rate of morbidity and mortality. Unfortunately, several randomized clinical trials aiming at limiting the hematoma expansion (HE) in the acute phase of ICH have not shown significant effects in improving the functional outcomes. Blood pressure variability (BPV) is common following ICH. High BPs have been associated with increased risk of bleeding and HE. Conversely, recurrent sudden decrease in BP promote perihematomal ischemia. However, it is still not clear weather BPV causes adverse prognosis following ICH or large ICHs cause fluctuations in BP. In the current review, we will discuss the mechanistic pathophysiology of BPV and the evidence regarding the role of BPV on the ICH outcomes.

Keywords: Blood pressure variability; Hematoma expansion; Intracerebral hemorrhage.

Publication types

  • Review

MeSH terms

  • Blood Pressure
  • Cerebral Hemorrhage* / complications
  • Cerebral Hemorrhage* / therapy
  • Hematoma*
  • Humans
  • Prognosis