Superior field performance of waxy corn engineered using CRISPR-Cas9

Nat Biotechnol. 2020 May;38(5):579-581. doi: 10.1038/s41587-020-0444-0. Epub 2020 Mar 9.


We created waxy corn hybrids by CRISPR-Cas9 editing of a waxy allele in 12 elite inbred maize lines, a process that was more than a year faster than conventional trait introgression using backcrossing and marker-assisted selection. Field trials at 25 locations showed that CRISPR-waxy hybrids were agronomically superior to introgressed hybrids, producing on average 5.5 bushels per acre higher yield.

MeSH terms

  • CRISPR-Cas Systems
  • Crop Production
  • Gene Editing / methods
  • Genetic Introgression
  • Plant Proteins / genetics*
  • Quantitative Trait Loci*
  • Sequence Deletion
  • Zea mays / genetics
  • Zea mays / growth & development*


  • Plant Proteins