Is long-term PM 1 exposure associated with blood lipids and dyslipidemias in a Chinese rural population?

Environ Int. 2020 May;138:105637. doi: 10.1016/j.envint.2020.105637. Epub 2020 Mar 8.

Abstract

Background: Air pollution has been shown to be associated with blood lipid levels. However, studies on long-term ambient particulate matter with aerodynamic diameter ≤1 μm (PM1) exposure in high-exposure areas are still limited. This study aimed to explore the associations among long-term PM1 exposure, blood lipids and dyslipidemias.

Methods: Baseline data of The Henan Rural Cohort study was used in present study, including a total of 39,259 participants aged from 18 to 79 years. Daily levels of PM1 were estimated by a spatiotemporal model using ground-level measurements of PM1, satellite remote sensing data and other predictors, according to participants' home addresses. Individual exposure to PM1 was the 3-year average before baseline investigation. Linear regression and logistic regression models were applied to examine the associations among PM1, blood lipids ((total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C)), and prevalence of dyslipidemias.

Results: The 3-year concentration of PM1 was 55.7 ± 2.1 μg/m3. Each 1 μg/m3 increment of PM1 was associated with an increase of 0.21% (95% confidence interval (CI): 0.11%-0.31%) in TC and 0.75% (95% CI: 0.61%-0.90%) in LDL-C, while decrease of 2.68% (95% CI: 2.43%-2.93%) in TG and 0.47% (95% CI: 0.35%-0.59%) in HDL-C. Each 1 μg/m3 increase in PM1 was associated with 6% (95% CI: 4%-8%), 3% (95% CI: 2%-5%) and 5% (95% CI: 3%-7%) higher risks of hypercholesterolemia, hyperbetalipoproteinemia and hypoalphalipoproteinemia. Sex, age and BMI statistically modified the associations between PM1 with blood lipid levels and dyslipidemias.

Conclusions: Higher PM1 exposure was associated with adverse changes of blood lipid levels and dyslipidemias. Males, older and overweight participants were susceptive to the adverse effects of PM1.

Keywords: Blood lipids; Cohort study; Dyslipidemia; PM(1); Rural areas.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Air Pollutants* / analysis
  • China / epidemiology
  • Cohort Studies
  • Dyslipidemias* / epidemiology
  • Humans
  • Lipids
  • Male
  • Middle Aged
  • Particulate Matter / analysis
  • Rural Population
  • Young Adult

Substances

  • Air Pollutants
  • Lipids
  • Particulate Matter