Predictive factors for successful pregnancy in an egg-sharing donation program

JBRA Assist Reprod. 2020 May 1;24(2):163-169. doi: 10.5935/1518-0557.20190087.

Abstract

Objective: To investigate the predictive factors for successful pregnancy in oocyte recipient ICSI cycles in an egg-sharing donation program.

Methods: Analysed data were obtained via chart review of 1505 vitrified oocytes donated from 268 patients to 225 oocyte recipients, undergoing 307 ICSI cycles. Patients were participating in an egg-sharing donation program between January 2015 and May 2017. Adjusted generalised linear models were used to investigate the impact of oocyte donor and recipient characteristics on recipients' pregnancy achievement.

Results: Implantation rate in the oocyte donor was highly correlated with pregnancy achievement in the oocyte recipient's cycles (ExpB: 1.181, CI: 1.138-1.226, p<0.001). The ROC curve analysis demonstrated that the implantation rate in the oocyte donor has a strong predictive value for pregnancy success in the oocyte recipient (area under the curve: 0.98, CI: 0.95-0.99, p<0.001). Pregnancy in oocyte donors and recipients were highly associated (ExpB: 54.6, CI: 28.1-105.8, p<0.001), regardless of the oocyte recipient's age. In oocyte recipients, the high-quality embryos rates on days 2 (ExpB: 3.397, CI: 1.635-7.054, p=0.001) and 3 (ExpB: 6.629, CI: 1.185-37.092, p=0.031), and blastocyst development rates (ExpB: 2.331, CI: 1.086-5.001, p=0.030) were positively associated with pregnancy outcome.

Conclusion: The strong association in pregnancy success between donors and recipients, and the lack of correlation between donor characteristics and cycles' outcomes, demonstrate the power of oocyte quality on the success of ICSI treatment.

Keywords: egg donation; implantation; oocyte donor; pregnancy; vitrification.

MeSH terms

  • Adult
  • Embryo Implantation / physiology
  • Female
  • Fertilization in Vitro / statistics & numerical data*
  • Humans
  • Oocyte Donation*
  • Oocytes / physiology
  • Pregnancy
  • Pregnancy Outcome / epidemiology*
  • Tissue Donors / statistics & numerical data*
  • Vitrification
  • Young Adult