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Review
. 2020 Jan 9:9:2019-10-1.
doi: 10.7573/dic.2019-10-1. eCollection 2020.

Clinical use of Capilen, a liposomal cream based on fresh plant extracts enriched with omega fatty acids

Luca Giacomelli  1 , Alessandra Moglia  2 , Gianedoardo Losa  3 , Pietro Quaglino  4
Affiliations
Review

Clinical use of Capilen, a liposomal cream based on fresh plant extracts enriched with omega fatty acids

Luca Giacomelli et al. Drugs Context. .

Abstract

The skin is the largest organ in the human body; beyond its regulatory and sensory roles, it is meant to protect and act like a barrier against foreign matter. Products intended to restore the skin health should reintegrate the structure of the stratum corneum in which the corneocytes are surrounded by the intercellular lipid lamellae that maintain both corneum integrity and skin permeability barrier. Capilen is a specific liposomal formulation based on a technology through which highly concentrated fresh plant extracts are conveyed into a jelly-like liposomal vehicle and combined with plant-derived omega-3, -6, -7, and -9 fatty acids, phospholipids, and precursors of ceramides. Its components have been widely investigated and produced clinical benefits in atopic dermatitis, bedsores, scars, inflammatory lesions of the skin, and generally whenever signs of xerosis cutis were present. Liposomes contribute to restore the surface lipid layer of the skin and to deliver substances in the activity site. This liposomal cream was proven to limit and delay the occurrence of radiodermatitis in breast cancer patients, and as an add-on provided complete healing of bedsore lesions in geriatric subjects.

Keywords: liposomal cream; liposomes; omega fatty acids; skin disorders.

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Conflict of interest statement

Disclosure and potential conflicts of interest: Alessandra Moglia is an employee of Vivendo Pharma, Cham, Switzerland. Edoardo Losa is an employee of Capietal Italia, Bergamo, Italy. Luca Giacomelli is Visiting Professor at the University of Genoa, Department of Surgical Sciences and Integrated Diagnostics, and is also Director Polistudium srl, Milan, Italy. Pietro Quaglino has nothing to disclose. The International Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests form for the authors is available for download at http://www.drugsincontext.com/wp-content/uploads/2019/11/dic.2019-10-1-COI.pdf

Figures

Figure 1
Figure 1
‘Filler’ effect of CLC.
Figure 2
Figure 2
Comparison between fresh and dried plant characteristics for Symphyti officinalis. Adapted from Tobler et al.
Figure 3
Figure 3
Incidence of overall toxicity (Panel A) and G3 toxicity (Panel B) in breast cancer patients treated with CLC and in a historical control group. Adapted from Stefanelli.
Figure 4
Figure 4
Time to occurrence of radiodermatitis in breast cancer patients treated with CLC and in a historical control group. Adapted from Stefanelli.
See this image and copyright information in PMC

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