The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects

Yuening Kang; Yuetian Yu; Liangjing Lu

doi:10.1080/12298093.2020.1722576

The Role of Pentraxin 3 in Aspergillosis: Reality and Prospects

Mycobiology. 2020 Feb 8;48(1):1-8. doi: 10.1080/12298093.2020.1722576. eCollection 2020.

Authors

Yuening Kang¹, Yuetian Yu², Liangjing Lu¹

Affiliations

¹ Department of Rheumatology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
² Department of Critical Care Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Abstract

Pentraxin 3 (PTX3) is a soluble pattern recognition receptor (PRR), which is produced by several kinds of cells, such as neutrophils, dendritic cells, macrophages, and epithelial cells. PTX3 is known to play an important protective effect against Aspergillus. Genetic linkage in gene-targeted mice and human PTX3 plays a non-redundant role in the immune protection against specific pathogens, especially Aspergillus. Recent studies have shown that the polymorphism of PTX3 is associated with increased susceptibility to invasive aspergillosis (IA). In this review, we provide an overview of these studies that underline the potential of PTX3 in diagnosis and therapy of IA.

Keywords: Aspergillus; Pentraxin 3; invasive aspergillosis.

Publication types

Review

Grants and funding

This work was supported by the National Key Research and Development Program of China [2017YFC0909002], Scientific Research Project of Shanghai Municipal Health Bureau [201840006] and the National Natural Science Foundation of China [Grant No: 81373209].