Histone H3 variants at the root of metastasis

Mol Cell Oncol. 2020 Jan 10;7(2):1684128. doi: 10.1080/23723556.2019.1684128. eCollection 2020.


Chromatin remodeling is at the root of any cell fate decision, laying the foundation for the necessary reprogramming to occur. Our work shows histone H3 variants as a new addition to the ever-growing body of epigenetic regulators, one that is essential for cell fate transitions in carcinoma cells to promote tumor progression and metastasis.

Keywords: epigenetics; histone H3.3; histone chaperones; metastasis; tumor progression.