COVID-19 Patients' Clinical Characteristics, Discharge Rate, and Fatality Rate of Meta-Analysis

J Med Virol. 2020 Jun;92(6):577-583. doi: 10.1002/jmv.25757. Epub 2020 Mar 23.

Abstract

The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. The available data of 1994 patients in 10 literatures were included in our study. The main clinical symptoms of COVID-19 patients were fever (88.5%), cough (68.6%), myalgia or fatigue (35.8%), expectoration (28.2%), and dyspnea (21.9%). Minor symptoms include headache or dizziness (12.1%), diarrhea (4.8%), nausea and vomiting (3.9%). The results of the laboratory showed that the lymphocytopenia (64.5%), increase of C-reactive protein (44.3%), increase of lactic dehydrogenase (28.3%), and leukocytopenia (29.4%) were more common. The results of single-arm meta-analysis showed that the male took a larger percentage in the gender distribution of COVID-19 patients 60% (95% CI [0.54, 0.65]), the discharge rate of COVID-19 patients was 52% (95% CI [0.34,0.70]), and the fatality rate was 5% (95% CI [0.01,0.11]).

Keywords: 2019-nCoV; COVID-19; clinical characteristics; discharge rate; fatality rate; meta-analysis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Betacoronavirus / pathogenicity
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • China / epidemiology
  • Coronavirus Infections / diagnosis
  • Coronavirus Infections / epidemiology*
  • Coronavirus Infections / mortality
  • Coronavirus Infections / physiopathology*
  • Cough / blood
  • Cough / diagnosis
  • Cough / physiopathology
  • Dyspnea / blood
  • Dyspnea / diagnosis
  • Dyspnea / physiopathology
  • Female
  • Fever / blood
  • Fever / diagnosis
  • Fever / physiopathology
  • Humans
  • Incidence
  • Lymphopenia / blood
  • Lymphopenia / diagnosis
  • Lymphopenia / physiopathology
  • Male
  • Pandemics*
  • Patient Discharge / statistics & numerical data*
  • Pneumonia, Viral / diagnosis
  • Pneumonia, Viral / epidemiology*
  • Pneumonia, Viral / mortality
  • Pneumonia, Viral / physiopathology*
  • Sex Factors
  • Survival Analysis

Substances

  • Biomarkers
  • C-Reactive Protein

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2