Bioorthogonal-targeted 1064 nm excitation theranostic nanoplatform for precise NIR-IIa fluorescence imaging guided efficient NIR-II photothermal therapy

Biomaterials. 2020 Jun:243:119934. doi: 10.1016/j.biomaterials.2020.119934. Epub 2020 Mar 2.

Abstract

Application of 1064 nm activatable NIR-IIa fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) results in high-resolution imaging and good deep-tissue therapy, respectively. Combining NIR-IIa FI with NIR-II PTT may allow precise diagnosis guided efficient treatment of deep-tissue tumors. However, designing a 1064 activatable theranostic nanoplatform using a single dye for both NIR-IIa FI and NIR-II PTT is a challenge. Herein, we synthesized squaraine-based semiconducting polymer nanoparticles (PSQPNs-DBCO) that were excited by a 1064 nm laser for precise NIR-IIa fluorescence imaging guided NIR-II PTT treatment. Combined with bioorthogonal labeling technology, the PSQPNs-DBCO largely accumulated in the tumor section, extremely enhancing signal-to-background ratio (SBR) of imaging and NIR-II PTT efficiency of tumor in live colorectal-bearing animals.

Keywords: Bioorthogonal labelling; NIR-II photothermal therapy; NIR-IIa fluorescence imaging; Precision medicine; Theranostic nanoplatform.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Nanoparticles*
  • Optical Imaging
  • Phototherapy
  • Photothermal Therapy
  • Polymers
  • Precision Medicine*
  • Theranostic Nanomedicine

Substances

  • Polymers