Crosstalk Among Circadian Rhythm, Obesity and Allergy

Int J Mol Sci. 2020 Mar 10;21(5):1884. doi: 10.3390/ijms21051884.


The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.

Keywords: allergy; circadian clock system; immune system; metabolic system; obesity.

Publication types

  • Review

MeSH terms

  • Animals
  • Circadian Clocks
  • Circadian Rhythm*
  • Energy Metabolism
  • Humans
  • Hypersensitivity / metabolism*
  • Obesity / metabolism*