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. 2020 Mar 10;21(5):1884.
doi: 10.3390/ijms21051884.

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Free PMC article

Crosstalk Among Circadian Rhythm, Obesity and Allergy

Kanami Orihara et al. Int J Mol Sci. .
Free PMC article


The circadian clock system works not only as a cellular time-keeper but also as a coordinator for almost all physiological functions essential to maintaining human health. Therefore, disruptions or malfunctions of this system can cause many diseases and pre-symptomatic conditions. Indeed, previous studies have indicated that disrupted clock gene expression rhythm is closely related to obesity, and that allergic diseases can be regulated by controlling peripheral clocks in organs and tissues. Moreover, recent studies have found that obesity can lead to immune disorders. Accordingly, in this review, we assess the connection between obesity and allergy from the point of view of the circadian clock system anew and summarize the relationships among the circadian clock system, obesity, and allergy.

Keywords: allergy; circadian clock system; immune system; metabolic system; obesity.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
Relationship among the circadian clock system, obesity, and immunity. In a healthy state, the circadian clock system, the metabolic system, and the immune system interact and function normally. However, when one of the gears became out of position for some reason, other systems will be led to malfunction.

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