Emtricitabine

Profiles Drug Subst Excip Relat Methodol. 2020:45:55-91. doi: 10.1016/bs.podrm.2019.10.003. Epub 2019 Dec 6.

Abstract

Emtricitabine (Emtriva, FTC) is an antiviral medicine which decreases the body's amount of HIV. Emtricitabine on of Anti-HIV drugs slow down or protect the immune system against damage and reduce the risk of diseases related to developing of AIDS. Emtricitabine use also for treatment of hepatitis B virus. Emtricitabine is a drug class known as nucleoside reversing transcriptase inhibitors (NRTIs). In view of Emtricitabine's clinical significance, a thorough review of the physical and pharmaceutical characteristics and details of the multiple analytical techniques used to test the drug in pharmaceutical and biological systems was conducted. The methods investigated include identification test, Spectroscopy, chromatography, electrochemicals, and Thermal. Beside the analytical profile, the degradation and stability of Emtricitabine, its pharmacology and pharmacokinetics, Pharmaceutical Applications, Mechanism of Action, dosage forms and dose, ADME profile, and interactions have been debated.

Keywords: Clinical applications; Description; Emtricitabine; Methods of analysis; Methods of preparation; Physical characteristics; Stability.

MeSH terms

  • Anti-HIV Agents / pharmacology*
  • Emtricitabine / pharmacology*
  • HIV Infections / drug therapy
  • Hepatitis B / drug therapy
  • Humans
  • Reverse Transcriptase Inhibitors / pharmacology*

Substances

  • Anti-HIV Agents
  • Reverse Transcriptase Inhibitors
  • Emtricitabine