The Role of Dietary Antioxidants on Oxidative Stress in Diabetic Nephropathy

Iran J Kidney Dis. 2020 Mar;14(2):81-94.

Abstract

Diabetic nephropathy (ND) is the leading cause of end-stage renal disease and oxidative stress (OS) has been recognized as a key factor in the pathogenesis and progression. Hyperglycemia, reactive oxygen species, advanced glycation end products, arterial pressure, insulin resistance, decrease in nitric oxide, inflammatory markers, and cytokines, among others; are involved in the presence of OS on ND. This revision focus on diverse studies in experimental and human models with diabetes and DN that has been demonstrated beneficial effects of different dietary antioxidant as resveratrol, curcumin, selenium, soy, catechins, α-lipoic acid, coenzyme Q10, omega-3 fatty acids, zinc, vitamins E and C, on OS and the capacity for antioxidant response. Therefore, this interventions could have a positive clinical impact on DN.

Publication types

  • Review

MeSH terms

  • Antioxidants / pharmacology*
  • Biomarkers / metabolism
  • Cytokines / metabolism
  • Diabetic Nephropathies / metabolism
  • Diabetic Nephropathies / prevention & control*
  • Dietary Supplements
  • Glycation End Products, Advanced
  • Humans
  • Hyperglycemia / metabolism*
  • Kidney / metabolism*
  • Nitric Oxide / metabolism
  • Oxidative Stress / drug effects
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism

Substances

  • Antioxidants
  • Biomarkers
  • Cytokines
  • Glycation End Products, Advanced
  • Reactive Oxygen Species
  • Nitric Oxide