Ultrasound-responsive highly biocompatible nanodroplets loaded with doxorubicin for tumor imaging and treatment in vivo

Drug Deliv. 2020 Dec;27(1):469-481. doi: 10.1080/10717544.2020.1739170.

Abstract

As an injectable anticancer drug delivery system, the biological safety of nanocarriers is the most important prerequisite for their clinical application. The objective of our study was to synthesize special ultrasound-responsive highly biocompatible chitosan nanodroplets (BCNDs), observe their spatiotemporally control the delivery of doxorubicin (DOX) in vivo. The experimental results showed that the BCNDs were successfully prepared with high biosafety in vivo and great ultrasound imaging ability. DOX-BCNDs promoted the anticancer effects of DOX in vivo and inhibited the development of tumors. They also reduced the side effects to the heart and kidneys. In conclusion, BCNDs are a new type of smart nanocarrier with high biocompatibility and efficacy have great potential to be used in the clinic.

Keywords: High biocompatibility; chitosan nanodroplets; contrast-enhanced ultrasound imaging; drug delivery system; spatiotemporally controlled delivery.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / administration & dosage
  • Antibiotics, Antineoplastic / toxicity
  • Cell Line, Tumor
  • Chitosan / chemistry
  • Doxorubicin / administration & dosage*
  • Doxorubicin / toxicity
  • Drug Carriers / chemistry
  • Drug Delivery Systems*
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Nanoparticles*
  • Neoplasms / prevention & control
  • Ultrasonography*

Substances

  • Antibiotics, Antineoplastic
  • Drug Carriers
  • Doxorubicin
  • Chitosan

Grants and funding

This work was supported by National Natural Science Foundation of China [No. 81771843], Science and Technology Developing Program of Shandong Provincial Government of China [No. 2017GSF18107] and the Science and Technology Development Planning of Jinan City in Shandong province of China [No. 201704084].