Theoretical Analysis for the Safe Form and Dosage of Amygdalin Product

Anticancer Agents Med Chem. 2020 Mar 13. doi: 10.2174/1871520620666200313163801. Online ahead of print.

Abstract

Indroduction: This article presents a theoretical analysis of the safe dosage form and its dosage of the amygdalin derivative. By making a precise socio-anthropological analysis of the life of the ancient people of Botra (Hunza people, Burusho / Brusho people), we come to the hypothesis, which is confirmed by two proofs, through a number of modern quantum-mechanical, molecular-topological and bio analytical checks.

Metodology: The proposed hypothesis that undergoes theoretical and logical analysis to confirm and/or reject it. The methodological scheme is: determining the optimal chemical formula, determination of the pharmaceutical molecular form and determination of the drug dose.

Results: A convenient, harmless, form of amygdalin derivative is available that has the same biological and chemical activity and could be used in conservative clinical oncology. The article also presents a theoretical comparative analysis of biochemical reactivity in in vivo and in vitro media, by which we also determine the recommended dosage for patient administration. Based on a comparative analysis of the data, obtained in published clinical studies of amygdalin, is presented and summarized a scheme of the anti-tumor activity of proposed by the author's molecular form.

Conclusion: The hydrolyzed to amide / carboxylic acid cyano / nitrile glycosides are potential drugs. Their biological activity remains unchanged, but their toxicity is many times lower than unmodified native molecules. The amygdalin / dhurrin-derived amide is only one of the dozens of studies we have conducted and we make this claim. Other substances in these groups with pronounced biological activity (including anti-tumor) are the hydrolyzed nitrile groups by Prunasin, Lucumin, Vicianin, Sambunigrin, Dhurrin, Taxiphyllin, Zierin, Preteacin, p-Glucosyloxymandelonitrile, Linamarin, Lotaustralin, Acaciapetalin, Triglochinin, Dejdaclin, Tetraphyllin A, Tetrallin B, Gynocardin etc., to their amide/carboxylic acid.

Keywords: PM6; PM7; TD-DFT; amygdalin; oncology; pharmacological activity.