The Impact of Oxytocin Vaginal Gel on Sexual Function in Postmenopausal Women: A Randomized Controlled Trial

J Sex Marital Ther. 2020;46(4):377-384. doi: 10.1080/0092623X.2020.1738606. Epub 2020 Mar 13.


Many postmenopausal women suffer from sexual dysfunction mostly due to the vulvovaginal atrophy. The aim of this study was to assess the effect of vaginal oxytocin gel on sexual function of postmenopausal women. This study was conducted on 96 postmenopausal women with symptoms of vaginal atrophy and sexual dysfunction who were randomly recruited into two groups of oxytocin vaginal gel (400 IU, n = 48) or placebo (n = 48). The PH, vaginal maturation index, and sexual function (using Female Sexual Function Index) of the participants were measured at the beginning of the study and eight weeks later. The vaginal maturation index and the PH of the vagina improved in the oxytocin group compared to those of the placebo. All domains of sexual function including desire, arousal, lubrication, pain, sexual satisfaction, and total score of sexual function improved significantly in the oxytocin gel compared to the control group (p < 0.0001). The results of this study showed that the administration of oxytocin vaginal gel could significantly improve vaginal atrophy as well as sexual function in postmenopausal women. Therefore, using vaginal oxytocin gel for sexual dysfunction in postmenopausal women who are not interested in hormone therapy is recommended.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Atrophy / drug therapy*
  • Female
  • Humans
  • Libido
  • Middle Aged
  • Orgasm
  • Oxytocin / therapeutic use*
  • Postmenopause*
  • Sexual Arousal
  • Sexual Dysfunction, Physiological / drug therapy*
  • Vagina / drug effects*
  • Vaginal Creams, Foams, and Jellies / therapeutic use*


  • Vaginal Creams, Foams, and Jellies
  • Oxytocin