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[Online ahead of print]

Exhausted Phenotype of Follicular CD8 T Cells in CVID

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Exhausted Phenotype of Follicular CD8 T Cells in CVID

Adam Klocperk et al. J Allergy Clin Immunol.

Abstract

Follicular CD8 T cells are expanded in germinal centers of CVID patients with lymphadenopathy, show increased proliferation, an exhaustion-associated phenotype and IL-10 production and may thus potentially contribute to germinal center dysregulation in some CVID patients.

Keywords: CD8 T cell; CVID; CXCR5; IL-10; exhaustion; follicular CD8 T cell; germinal center; immunodeficiency; lymph node.

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