Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species

Infect Genet Evol. 2020 Aug;82:104285. doi: 10.1016/j.meegid.2020.104285. Epub 2020 Mar 10.


The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International Concern. However, so far, there are still controversies about the source of the virus and its intermediate host. Here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including Paguma larvata, Paradoxurus hermaphroditus, Civet, Aselliscus stoliczkanus and Rhinolophus sinicus, and was in the same branch of the phylogenetic tree. However, genome and ORF1a homology show that the virus is not the same coronavirus as the coronavirus derived from these five animals, whereas the virus has the highest homology with Bat coronavirus isolate RaTG13.

Keywords: 2019 Coronavirus disease (COVID-19); Genetic evolution; Genome; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Structural protein.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Betacoronavirus / classification
  • Betacoronavirus / genetics*
  • Chiroptera / virology
  • Coronavirus / classification
  • Coronavirus / genetics*
  • Coronavirus / isolation & purification
  • Evolution, Molecular*
  • Mammals / classification
  • Mammals / virology
  • Mutation
  • Phylogeny
  • RNA, Viral
  • SARS-CoV-2
  • Sequence Homology, Nucleic Acid


  • RNA, Viral