In achondroplasia, lumbar spinal stenosis arises from congenital dysplasia and acquired degenerative changes. We here aimed to describe the changes of the lumbar spinal canal and intervertebral disc in adults. We included 18 adults (age ≥ 18 years) with achondroplasia and lumbar spinal stenosis. Radiographs were used to analyze spinal-pelvic angles. Antero-posterior diameter of the spinal canal and the grade of disc degeneration were measured by MRI. Antero-posterior diameters of the spinal canal differed by spinal level (P < 0.05), with lower values observed at T12-L1, L1-2 and L2-3. Degrees of disc degeneration differed by intervertebral level, with higher degrees observed at L1-2, L2-3 and L3-4. A significant correlation was found between disc degeneration and thoraco-lumbar kyphosis at L2-3, between antero-posterior diameter of the spinal canal and lumbar lordosis at T12-L1 and L2-3, and between antero-posterior diameter of the spinal canal and thoraco-lumbar kyphosis at L1-2. Unlike the general population, spinal stenosis and disc degeneration involve the upper part of the lumbar spine in adults with achondroplasia, associated with thoraco-lumbar kyphosis and loss of lumbar lordosis.
Conflict of interest statement
The authors declare no competing interests.
Spondylectomy and lateral lumbar interbody fusion for thoracolumbar kyphosis in an adult with achondroplasia: A case report.Medicine (Baltimore). 2017 Dec;96(49):e8983. doi: 10.1097/MD.0000000000008983. Medicine (Baltimore). 2017. PMID: 29245270 Free PMC article.
[Correlation of lumbar disc degeneration and spinal-pelvic sagittal balance].Zhonghua Yi Xue Za Zhi. 2013 Apr 16;93(15):1123-8. Zhonghua Yi Xue Za Zhi. 2013. PMID: 23902878 Chinese.
Congenital lumbar spinal stenosis: a prospective, control-matched, cohort radiographic analysis.Spine J. 2005 Nov-Dec;5(6):615-22. doi: 10.1016/j.spinee.2005.05.385. Spine J. 2005. PMID: 16291100 Clinical Trial.
Narrowing of thoraco-lumbar spinal canal in achondroplasia.J Neurosurg Sci. 1989 Apr-Jun;33(2):185-96. J Neurosurg Sci. 1989. PMID: 2677264 Review.
Biomechanical analysis of the spino-pelvic organization and adaptation in pathology.Eur Spine J. 2011 Sep;20 Suppl 5(Suppl 5):609-18. doi: 10.1007/s00586-011-1928-x. Epub 2011 Aug 2. Eur Spine J. 2011. PMID: 21809016 Free PMC article. Review.