Pathways Involved in Premature Ovarian Failure: A Systematic Review of Experimental Studies

Curr Pharm Des. 2020;26(18):2087-2095. doi: 10.2174/1381612826666200316160145.


Premature ovarian failure (POF), which may be undetectable for a long time, is associated with impaired fertility. The mechanisms involved in the pathogenesis of POF as well as the concomitant treatments are still unclear. Although many data exist, mainly produced by the study of transgenic animals under various experimental conditions, they remain fragmented. A systematic review of the pathways involved in premature ovarian failure was conducted. Data extraction was performed from experimental studies until 2019. The molecular processes and their correlation with the follicular developmental stage have been described. Furthermore, the effects in other cells, such as oocytes, granulosa and theca cells have been reported. An overall estimation was conducted.

Keywords: Fertility; POF; follicular; folliculogenesis; ovary; transgenic..

Publication types

  • Systematic Review

MeSH terms

  • Animals
  • Female
  • Fertility
  • Humans
  • Primary Ovarian Insufficiency* / genetics
  • Theca Cells