Clinical Features of 69 Cases With Coronavirus Disease 2019 in Wuhan, China

Clin Infect Dis. 2020 Jul 28;71(15):769-777. doi: 10.1093/cid/ciaa272.

Abstract

Background: From December 2019 to February 2020, 2019 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a serious outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China. Related clinical features are needed.

Methods: We reviewed 69 patients who were hospitalized in Union hospital in Wuhan between 16 January and 29 January 2020. All patients were confirmed to be infected with SARS-CoV-2, and the final date of follow-up was 4 February 2020.

Results: The median age of 69 enrolled patients was 42.0 years (interquartile range 35.0-62.0), and 32 patients (46%) were men. The most common symptoms were fever (60 [87%]), cough (38 [55%]), and fatigue (29 [42%]). Most patients received antiviral therapy (66 [98.5%] of 67 patients) and antibiotic therapy (66 [98.5%] of 67 patients). As of 4 February 2020, 18 (26.9%) of 67 patients had been discharged, and 5 patients had died, with a mortality rate of 7.5%. According to the lowest SpO2 during admission, cases were divided into the SpO2 ≥ 90% group (n = 55) and the SpO2 < 90% group (n = 14). All 5 deaths occurred in the SpO2 < 90% group. Compared with SpO2 ≥ 90% group, patients of the SpO2 < 90% group were older and showed more comorbidities and higher plasma levels of interleukin (IL) 6, IL10, lactate dehydrogenase, and C reactive protein. Arbidol treatment showed tendency to improve the discharging rate and decrease the mortality rate.

Conclusions: COVID-19 appears to show frequent fever, dry cough, and increase of inflammatory cytokines, and induced a mortality rate of 7.5%. Older patients or those with underlying comorbidities are at higher risk of death.

Keywords: Wuhan; coronavirus; pneumonia.

MeSH terms

  • Adult
  • Aged
  • Betacoronavirus / pathogenicity
  • C-Reactive Protein / metabolism
  • China
  • Coronavirus Infections / metabolism
  • Coronavirus Infections / pathology*
  • Coronavirus Infections / virology*
  • Cough / metabolism
  • Cough / pathology
  • Cough / virology
  • Female
  • Fever / metabolism
  • Fever / pathology
  • Fever / virology
  • Hospitalization
  • Humans
  • Interleukin-10 / metabolism
  • Interleukin-6 / metabolism
  • Male
  • Middle Aged
  • Pandemics
  • Patient Discharge
  • Pneumonia, Viral / metabolism
  • Pneumonia, Viral / pathology*
  • Pneumonia, Viral / virology*

Substances

  • Interleukin-6
  • Interleukin-10
  • C-Reactive Protein

Supplementary concepts

  • COVID-19
  • severe acute respiratory syndrome coronavirus 2