Erythema multiforme is associated to HLA-Aw33 and DRw53

Tissue Antigens. 1988 Sep;32(3):170-5. doi: 10.1111/j.1399-0039.1988.tb01654.x.

Abstract

Erythema multiforme is an acute eruption of the skin and mucous membranes of various aetiologies. Forty-one unrelated patients were HLA typed for 53 specificities of the HLA-A, B, C, DR and DQ series. Frequencies of Aw33 and DRw53 were significantly increased: Aw33, 17.0% in patients vs 2.8% in controls (corrected p = 0.01, relative risk = 7.2); DRw53, 70.7% in patients vs 30.5% in controls (corrected p = 0.0005, relative risk = 5.5).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Erythema Multiforme / genetics
  • Erythema Multiforme / immunology*
  • Erythema Multiforme / physiopathology
  • Female
  • Gene Frequency
  • HLA-A Antigens / immunology*
  • HLA-DR Antigens / immunology*
  • HLA-DRB4 Chains
  • Humans
  • Male
  • Middle Aged
  • Phenotype

Substances

  • HLA-A Antigens
  • HLA-A*33 antigen
  • HLA-DR Antigens
  • HLA-DR53
  • HLA-DRB4 Chains