Tumor burden is a potential marker of PARP inhibitor effects in ovarian cancer: a head-to-head observational series

J Ovarian Res. 2020 Mar 17;13(1):29. doi: 10.1186/s13048-020-00629-4.

Abstract

Background: Olaparib, a poly ADP-ribose polymerase (PARP) inhibitor, has proven to be effective and safe as maintenance therapy and multiline therapy in ovarian cancer, especially in patients with BRCA mutations. This study intended to observe the influence of tumor load on the efficacy and safety of olaparib in recurrent ovarian cancer.

Cases presentation: Three patients harbored gBRCAwt with low tumor load (LTL), while two women harbored BRCAmt with high tumor load (HTL) were recruited. Two of the three LTL patients achieved partial response, and the other showed stable disease. Both HTL patients were assessed to have progressive disease in a short time. Olaparib appears to be effective and safe for LTL recurrent ovarian cancer patients even if it is gBRCAwt, while the response is poor in HTL patients.

Conclusions: Tumor load may be another potential marker to predict the effect of PARP inhibitors. The present head-to-head observational series provides new evidence on this issue for further research from bench to bedside in the future.

Keywords: Olaparib; Potential marker; Recurrent ovarian cancer; Tumor burden.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Biomarkers
  • Biomarkers, Tumor
  • Biopsy
  • Female
  • Humans
  • Middle Aged
  • Ovarian Neoplasms / diagnostic imaging
  • Ovarian Neoplasms / drug therapy*
  • Ovarian Neoplasms / mortality
  • Ovarian Neoplasms / pathology*
  • Poly(ADP-ribose) Polymerase Inhibitors / therapeutic use*
  • Tomography, X-Ray Computed
  • Treatment Outcome
  • Tumor Burden
  • Ultrasonography

Substances

  • Antineoplastic Agents
  • Biomarkers
  • Biomarkers, Tumor
  • Poly(ADP-ribose) Polymerase Inhibitors