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Comment
. 2020 Mar 16;37(3):267-269.
doi: 10.1016/j.ccell.2020.02.011.

It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

Michael C Gundry  1 , Margaret A Goodell  2 , Lorenzo Brunetti  3
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It's All About MEis: Menin-MLL Inhibition Eradicates NPM1-Mutated and MLL-Rearranged Acute Leukemias in Mice

Michael C Gundry et al. Cancer Cell. .
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Abstract

Several acute myeloid leukemia genetic sub-types converge on high expression of HOX genes, critical for their self-renewal. A new orally bioavailable Menin-MLL inhibitor (VTP-50469) appears to promote their differentiation through direct effects on the HOX cofactor MEIS1, paving the way for clinical trials.

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