Novel Research Models for Staphylococcus aureus Small Colony Variants (SCV) Development: Co-pathogenesis and Growth Rate

doi:10.3389/fmicb.2020.00321

Review

. 2020 Feb 28:11:321.

doi: 10.3389/fmicb.2020.00321. eCollection 2020.

Novel Research Models for Staphylococcus aureus Small Colony Variants (SCV) Development: Co-pathogenesis and Growth Rate

James Lee^{1

2

3}, Peter S Zilm⁴, Stephen P Kidd^{1

2

3}

Affiliations

¹ Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia.
² Research Centre for Infectious Diseases, Adelaide, SA, Australia.
³ Australian Centre for Antimicrobial Resistance Ecology, Adelaide, SA, Australia.
⁴ Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.

PMID: 32184775
PMCID: PMC7058586
DOI: 10.3389/fmicb.2020.00321

Review

Novel Research Models for Staphylococcus aureus Small Colony Variants (SCV) Development: Co-pathogenesis and Growth Rate

James Lee et al. Front Microbiol. 2020.

. 2020 Feb 28:11:321.

doi: 10.3389/fmicb.2020.00321. eCollection 2020.

Authors

James Lee^{1

2

3}, Peter S Zilm⁴, Stephen P Kidd^{1

2

3}

Affiliations

¹ Department of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia.
² Research Centre for Infectious Diseases, Adelaide, SA, Australia.
³ Australian Centre for Antimicrobial Resistance Ecology, Adelaide, SA, Australia.
⁴ Faculty of Health and Medical Sciences, The University of Adelaide, Adelaide, SA, Australia.

PMID: 32184775
PMCID: PMC7058586
DOI: 10.3389/fmicb.2020.00321

Abstract

Staphylococcus aureus remains a great burden on the healthcare system. Despite prescribed treatments often seemingly to be successful, S. aureus can survive and cause a relapsing infection which cannot be cleared. These infections are in part due to quasi-dormant sub-population which is tolerant to antibiotics and able to evade the host immune response. These include Small Colony Variants (SCVs). Because SCVs readily revert to non-SCV cell types under laboratory conditions, the characterization of SCVs has been problematic. This mini-review covers the phenotypic and genetic changes in stable SCVs including the selection of SCVs by and interactions with other bacterial species.

Keywords: Staphylococcus aureus; co-colonization; continuous culture; prolonged growth; small colony variants.

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References

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[1] Abdelnour A., Arvidson S., Bremell T., Ryden C., Tarkowski A. (1993). The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect. Immun. 61 3879–3885. 10.1128/iai.61.9.3879-3885.1993 - DOI - PMC - PubMed

[2] Abdelnour A., Arvidson S., Bremell T., Ryden C., Tarkowski A. (1993). The accessory gene regulator (agr) controls Staphylococcus aureus virulence in a murine arthritis model. Infect. Immun. 61 3879–3885. 10.1128/iai.61.9.3879-3885.1993 - DOI - PMC - PubMed

[3] Arvidson S., Tegmark K. (2001). Regulation of virulence determinants in Staphylococcus aureus. Int. J. Med. Microbiol. 291 159–170. 10.1078/1438-4221-00112 - DOI - PubMed

[4] Arvidson S., Tegmark K. (2001). Regulation of virulence determinants in Staphylococcus aureus. Int. J. Med. Microbiol. 291 159–170. 10.1078/1438-4221-00112 - DOI - PubMed

[5] Atalla H., Gyles C., Mallard B. (2011). Staphylococcus aureus small colony variants (SCVs) and their role in disease. Anim. Health Res. Rev. 12 33–45. 10.1017/S1466252311000065 - DOI - PubMed

[6] Atalla H., Gyles C., Mallard B. (2011). Staphylococcus aureus small colony variants (SCVs) and their role in disease. Anim. Health Res. Rev. 12 33–45. 10.1017/S1466252311000065 - DOI - PubMed

[7] Baddour L. M., Christensen G. D. (1987). Prosthetic valve endocarditis due to small-colony staphylococcal variants. Rev. Infect. Dis. 9 1168–1174. 10.1093/clinids/9.6.1168 - DOI - PubMed

[8] Baddour L. M., Christensen G. D. (1987). Prosthetic valve endocarditis due to small-colony staphylococcal variants. Rev. Infect. Dis. 9 1168–1174. 10.1093/clinids/9.6.1168 - DOI - PubMed

[9] Balaban N. Q., Merrin J., Chait R., Kowalik L., Leibler S. (2004). Bacterial persistence as a phenotypic switch. Science 305 1622–1625. 10.1126/science.1099390 - DOI - PubMed

[10] Balaban N. Q., Merrin J., Chait R., Kowalik L., Leibler S. (2004). Bacterial persistence as a phenotypic switch. Science 305 1622–1625. 10.1126/science.1099390 - DOI - PubMed

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Novel Research Models for Staphylococcus aureus Small Colony Variants (SCV) Development: Co-pathogenesis and Growth Rate

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Novel Research Models for Staphylococcus aureus Small Colony Variants (SCV) Development: Co-pathogenesis and Growth Rate

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