Pityriasis rubra pilaris is a rare papulosquamous chronic skin disease. The disease often exists for years and is difficult to treat. Not only is it clinically similar to psoriasis vulgaris, but both diseases also have a similar cytokine profile. The successful use of biologicals is frequently reported in case reports. Studies with large numbers of cases are lacking.
Keywords: Biological therapy; Cytokine profile; Interleukin-17A inhibitor; Off-label use; Skin diseases, papulosquamous.