Modulation of metabolic functions through Cas13d-mediated gene knockdown in liver

Protein Cell. 2020 Jul;11(7):518-524. doi: 10.1007/s13238-020-00700-2.

Bingbing He^{1

2}, Wenbo Peng^{3

2

4}, Jia Huang^{1

2}, Hang Zhang³, Yingsi Zhou¹, Xiali Yang¹, Jing Liu⁵, Zhijie Li^{3

2}, Chunlong Xu¹, Mingxing Xue¹, Hui Yang⁶, Pengyu Huang^{7

8}

¹ Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
² College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
³ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
⁴ CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China.
⁵ Center for Animal Genomics, Agricultural Genome Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.
⁶ Institute of Neuroscience, State Key Laboratory of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai Research Center for Brain Science and Brain-Inspired Intelligence, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. huiyang@ion.ac.cn.
⁷ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. huangpy@shanghaitech.edu.cn.
⁸ CAS Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, 200031, China. huangpy@shanghaitech.edu.cn.

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