Recurrent Herpes Simplex Virus 2 Lymphocytic Meningitis in Patient with IgG Subclass 2 Deficiency

Emerg Infect Dis. 2020 Apr;26(4):748-750. doi: 10.3201/eid2604.190406.


We report a case of a patient with a lifetime history of 8 episodes of recurrent lymphocytic meningitis. Our findings suggest that susceptibility to recurrent lymphocytic meningitis might be caused by low serum IgG subclass 2 immunodeficiency.

Keywords: HSV-2; IgG2 immunodeficiency; RBLM; herpes simplex virus; meningitis; recurrent benign lymphocytic meningitis; viruses.

Publication types

  • Case Reports

MeSH terms

  • Herpes Simplex* / diagnosis
  • Herpes Simplex* / drug therapy
  • Herpesvirus 2, Human / genetics
  • Humans
  • Immunoglobulin G
  • Meningitis, Viral*
  • Recurrence


  • Immunoglobulin G