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. 2020 Mar 18;1-15.
doi: 10.1080/21645515.2020.1730658. Online ahead of print.

Human T Cell Glycosylation and Implications on Immune Therapy for Cancer

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Human T Cell Glycosylation and Implications on Immune Therapy for Cancer

Elien De Bousser et al. Hum Vaccin Immunother. .

Abstract

Glycosylation is an important post-translational modification, giving rise to a diverse and abundant repertoire of glycans on the cell surface, collectively known as the glycome. When focusing on immunity, glycans are indispensable in virtually all signaling and cell-cell interactions. More specifically, glycans have been shown to regulate key pathophysiological steps within T cell biology such as T cell development, thymocyte selection, T cell activity and signaling as well as T cell differentiation and proliferation. They are of major importance in determining the interaction of human T cells with tumor cells. In this review, we will describe the role of glycosylation of human T cells in more depth, elaborate on the importance of glycosylation in the interaction of human T cells with tumor cells and discuss the potential of cancer immunotherapies that are based on manipulating the glycome functions at the tumor immune interface.

Keywords: Glycosylation; engineering; glycan-binding protein; human T cell; immunotherapy.

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