Narcissistic and Borderline Personality Disorders: Relationship With Oxidative Stress

J Pers Disord. 2020 Mar;34(Suppl):6-24. doi: 10.1521/pedi.2020.34.supp.6.


The authors hypothesized that personality disorders characterized by interpersonal hypersensitivity would be associated with an elevated concentration of 8-hydroxy-2'-deoxyguanosine (8-OH-DG), the oxidized form of guanine, and a biomarker of oxidative stress burden. One hundred ninety-five male and female adults underwent semistructured diagnostic interviews, completed questionnaire measures of social cognition and emotional attribution, and had blood drawn for determination of plasma 8-OH-DG. A hierarchical linear regression model revealed that narcissistic and borderline personality disorders predicted 8-OH-DG level independently of the effects of age, gender, recent alcohol and cigarette use, current major depression, and posttraumatic stress disorder. In all subjects, 8-OH-DG level was also correlated with the number of borderline personality disorder symptoms present. Narcissistic and borderline personality disorders predicted oxidative stress burden independently of potentially confounding factors.

Keywords: 8-OH-DG; borderline personality disorder; disgust; emotion; narcissistic personality disorder; oxidative stress; personality disorder; stress.

MeSH terms

  • Adult
  • Borderline Personality Disorder* / diagnosis
  • Borderline Personality Disorder* / epidemiology
  • Comorbidity
  • Female
  • Humans
  • Male
  • Narcissism
  • Oxidative Stress
  • Personality Disorders / epidemiology