Effect of Gum Arabic (Acacia senegal) on C-reactive protein level among sickle cell anemia patients

BMC Res Notes. 2020 Mar 18;13(1):162. doi: 10.1186/s13104-020-05016-2.


Objectives: Inflammation is ongoing process among sickle cell anemia even during steady state. C reactive protein (CRP) is cardinal marker that utilized widely as inflammatory indicator. Gum Arabic (GA) is gummy exudates from Acacia senegal tree. Fermentation by colonic bacteria increases serum butyrate concentrations, so considered as prebiotic agent. Gum Arabic (GA) has anti-inflammatory activity through butyrate. Earlier we proved that regular intake of GA increased fetal hemoglobin and anti-oxidant capacity most likely through raised level of butyrate, which would ameliorate symptoms of sickle cell anemia. Best of our knowledge this is the first study conducted to investigate GA intake on inflammatory markers among sickle patients.

Results: This was a retrospective study conducted on stored samples from trial of Gum Arabic and sickle cell anemia. Quantitative CRP was measured by Mindray BS 200 before and after Gum Arabic consumption for 12 weeks. Daily intake of GA significantly decreased C reactive protein level (P.V = 001) (95% CI 0.943-3.098). No correlation between CRP and age, fetal hemoglobin, hemolysis markers and white blood cells. Our findings revealed novel effect of GA as anti-inflammatory agent could be consumed as natural dietary supplement to modulate disease severity and downregulate inflammatory process.

Trial registration: ClinicalTrials.gov Identifier: NCT02467257. Registered 3rd June 2015.

Keywords: CRP and butyrate; Gum Arabic; Inflammation; Sickle cell.

Publication types

  • Clinical Trial

MeSH terms

  • Acacia*
  • Adolescent
  • Adult
  • Anemia, Sickle Cell / blood
  • Anemia, Sickle Cell / drug therapy*
  • Anemia, Sickle Cell / immunology
  • Anti-Inflammatory Agents / administration & dosage
  • Anti-Inflammatory Agents / pharmacology*
  • C-Reactive Protein / drug effects*
  • Child
  • Child, Preschool
  • Female
  • Gum Arabic / administration & dosage
  • Gum Arabic / pharmacology*
  • Humans
  • Inflammation / blood
  • Inflammation / drug therapy*
  • Inflammation / immunology
  • Male
  • Retrospective Studies
  • Sudan
  • Treatment Outcome
  • Young Adult


  • Anti-Inflammatory Agents
  • Gum Arabic
  • C-Reactive Protein

Associated data

  • ClinicalTrials.gov/NCT02467257