A nationwide survey on clinical practice patterns and bleeding complications of percutaneous native kidney biopsy in Japan

Clin Exp Nephrol. 2020 May;24(5):389-401. doi: 10.1007/s10157-020-01869-w. Epub 2020 Mar 18.

Abstract

Background: Practice patterns and bleeding complications of percutaneous native kidney biopsy (PNKB) have not recently been investigated and the Japanese Society of Nephrology performed a nationwide questionnaire survey in 2018.

Methods: The survey consisted of nine sections about PNKB: (1) general indications; (2) indications for high-risk patients; (3) informed consent; (4) pre-biopsy evaluation; (5) procedures; (6) sedation; (7) post-biopsy hemostasis, bed rest, and examinations; (8) bleeding complications; and (9) specimen processing. A supplementary survey examined bleeding requiring transcatheter arterial embolization (TAE).

Results: Overall, 220 directors of facilities (nephrology facility [NF], 168; pediatric nephrology facility [PF], 52) completed the survey. Indications, procedures, and monitoring protocols varied across facilities. Median lengths of hospital stay were 5 days in NFs and 6 days in PFs. Gauge 14, 16, 18 needles were used in 5%, 56%, 33% in NFs and 0%, 63%, 64% in PFs. Mean limits of needle passes were 5 in NFs and 4 in PFs. The bed rest period was 16-24 h in 60% of NFs and 65% of PFs. Based on 17,342 PNKBs, incidence rates of macroscopic hematuria, erythrocyte transfusion, and TAE were 3.1% (NF, 2.8%; PF, 6.2%), 0.7% (NF, 0.8%; PF, 0%), and 0.2% (NF, 0.2%; PF, 0.06%), respectively. Forty-six percent of facilities processed specimens all for light microscopy, immunofluorescence, and electron microscopy, and 21% processed for light microscopy only. Timing of bleeding requiring TAE varied among PNKB cases.

Conclusion: Wide variations in practice patterns of PNKB existed among facilities, while PNKBs were performed as safely as previously reported.

Keywords: Bleeding complication; Clinical practice pattern; Erythrocyte transfusion; Kidney biopsy; Macroscopic hematuria; Transcatheter arterial embolization.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biopsy / adverse effects*
  • Biopsy / instrumentation
  • Biopsy / methods
  • Child
  • Child, Preschool
  • Embolization, Therapeutic / statistics & numerical data*
  • Erythrocyte Transfusion / statistics & numerical data
  • Female
  • Health Facilities / statistics & numerical data*
  • Hematuria / etiology
  • Humans
  • Infant
  • Infant, Newborn
  • Informed Consent / statistics & numerical data
  • Japan
  • Kidney / pathology*
  • Length of Stay / statistics & numerical data
  • Male
  • Microscopy, Electron / statistics & numerical data
  • Middle Aged
  • Needles / statistics & numerical data
  • Nephrology / statistics & numerical data
  • Organizational Policy
  • Patient Selection
  • Pediatrics / statistics & numerical data
  • Postoperative Hemorrhage / etiology
  • Postoperative Hemorrhage / therapy*
  • Preoperative Care
  • Surveys and Questionnaires
  • Young Adult