Antimetastatic effect of amiloride in an animal tumour model

Anticancer Res. Nov-Dec 1988;8(6):1373-6.

Abstract

The diuretic Amiloride competitively inhibits the catalytic activity of the urokinase-type plasminogen activator on plasminogen in vitro. This effect was tested on a rat adenocarcinoma model and its invasive potential in the host lung. While the inhibitory effect on intact cell cultures of the tumour was slight, continuous exposure of tumour-injected animals to the drug completely prevented the formation of lung metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / pathology*
  • Amiloride / therapeutic use*
  • Animals
  • Antineoplastic Agents*
  • Female
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / pathology
  • Lung Neoplasms / secondary*
  • Mammary Neoplasms, Experimental / drug therapy
  • Mammary Neoplasms, Experimental / pathology*
  • Neoplasm Metastasis
  • Rats
  • Rats, Inbred F344

Substances

  • Antineoplastic Agents
  • Amiloride