Bromodomain AAA+ ATPases get into shape

Nucleus. 2020 Dec;11(1):32-34. doi: 10.1080/19491034.2020.1741304.

Abstract

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.

Keywords: Abo1; bromodomain AAA+ ATPase; histone chaperone.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • ATPases Associated with Diverse Cellular Activities / chemistry*
  • ATPases Associated with Diverse Cellular Activities / metabolism*
  • Cryoelectron Microscopy
  • Humans
  • Models, Molecular

Substances

  • ATPases Associated with Diverse Cellular Activities

Grant support

This work was supported by the Friedrich-Baur-Stiftung; H2020 European Research Council [H2020-MSC-I-2014-657244]; DFG [SFB1064]; DFG [SFB1309-325871075].