Divergent Mitochondrial Ribosomes in Unicellular Parasitic Protozoans

Swati Dass; Michael W Mather; Hangjun Ke

doi:10.1016/j.pt.2020.01.002

Divergent Mitochondrial Ribosomes in Unicellular Parasitic Protozoans

Trends Parasitol. 2020 Apr;36(4):318-321. doi: 10.1016/j.pt.2020.01.002. Epub 2020 Feb 19.

Authors

Swati Dass¹, Michael W Mather¹, Hangjun Ke²

Affiliations

¹ Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA.
² Center for Molecular Parasitology, Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA, USA. Electronic address: hk84@drexel.eduhk84@drexel.edu.

Abstract

The mitochondrion in parasitic protozoans is a clinically proven drug target. A specialized ribosome (mitoribosome) is required to translate genes encoded on the mitochondrial (mt) DNA. Despite the significance, little is known about mitoribosomes in many medically and economically important unicellular protozoans.

Keywords: Plasmodium; Trypanosoma; mitochondrial ribosome; mitochondrion; mitoribosome.

Publication types

Review

MeSH terms

Animals
Eukaryota / genetics*
Genetic Variation*
Genome, Mitochondrial / genetics
Genome, Protozoan / genetics*
Mitochondrial Ribosomes*
Parasites / genetics*

Abstract

Publication types

MeSH terms

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