Smoke inhalation injury in a 2-year-old domestic fire victim

Arch Pediatr. 2020 May;27(4):223-226. doi: 10.1016/j.arcped.2020.01.008. Epub 2020 Mar 16.


Smoke inhalation injury is common in victims of domestic fires, among whom children are the most vulnerable. Cyanide poisoning may occur in addition to carbon monoxide poisoning and is challenging to diagnose. In France, the recommended antidotes are hydroxocobalamin for cyanide and hyperbaric oxygen for carbon monoxide. We managed a 26-month-old girl who sustained smoke inhalation injury with both carbon monoxide and cyanide poisoning during a house fire. Despite hydroxocobalamin and sodium thiosulfate therapy combined with hyperbaric oxygen, she had residual neurological impairments 3 months after the injury. The treatment challenges and detailed neurological follow-up data are described.

Keywords: Child; Domestic fire; Hydroxocobalamin; Hyperbaric oxygen; Smoke inhalation.

Publication types

  • Case Reports

MeSH terms

  • Carbon Monoxide Poisoning / diagnosis*
  • Carbon Monoxide Poisoning / etiology
  • Carbon Monoxide Poisoning / therapy
  • Child, Preschool
  • Cyanides / poisoning*
  • Female
  • Fires*
  • Humans
  • Smoke Inhalation Injury / diagnosis*
  • Smoke Inhalation Injury / etiology
  • Smoke Inhalation Injury / therapy


  • Cyanides