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Review
. 2020 Mar 3:11:148.
doi: 10.3389/fphys.2020.00148. eCollection 2020.

Dipeptidyl Peptidase IV as a Muscle Myokine

Heidi A Kluess  1
Affiliations
Free PMC article
Review

Dipeptidyl Peptidase IV as a Muscle Myokine

Heidi A Kluess. Front Physiol. .
Free PMC article

Abstract

Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body. DPP-IV has multiple targets including cytokines, neuropeptides, and incretin hormones, and plays an important role in health and disease. Recent work suggests that skeletal muscle releases DPP-IV as a myokine and participates in control of muscle blood flow. However, few of the functions of DPP-IV as a myokine have been investigated to date and there is a poor understanding about what causes DPP-IV to be released from muscle.

Keywords: exercise; metalloproteases; muscle; peptidase; secretome; whey protein.

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Figures

FIGURE 1
FIGURE 1
Diagram of DPP-IV being shed from the membrane by metalloproteases (MMP) and the soluble DPP-IV cleaving full length NPY into NPY3-36.
See this image and copyright information in PMC

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