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. 2020 Mar 3;11:101.
doi: 10.3389/fendo.2020.00101. eCollection 2020.

DHEAS and Human Development: An Evolutionary Perspective

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Free PMC article

DHEAS and Human Development: An Evolutionary Perspective

Benjamin Campbell. Front Endocrinol (Lausanne). .
Free PMC article

Abstract

Adrenarche, the post-natal rise of DHEA and DHEAS, is unique to humans and the African Apes. Recent findings have linked DHEA in humans to the development of the left dorsolateral prefrontal cortex (LDPFC) between the ages of 4-8 years and the right temporoparietal junction (rTPJ) from 7 to 12 years of age. Given the association of the LDLPFC with the 5-to-8 transition and the rTPJ with mentalizing during middle childhood DHEA may have played an important role in the evolution of the human brain. I argue that increasing protein in the diet over the course of human evolution not only increased levels of DHEAS, but linked meat consumption with brain development during the important 5- to-8 transition. Consumption of animal protein has been associated with IGF-1, implicated in the development of the adrenal zona reticularis (ZR), the site of DHEAS production. In humans and chimps, the zona reticularis emerges at 3-4 years, along with the onset of DHEA/S production. For chimps this coincides with weaning and peak synaptogenesis. Among humans, weaning is completed around 2 ½ years, while synaptogenesis peaks around 5 years. Thus, in chimpanzees, early cortical maturation is tied to the mother; in humans it may be associated with post-weaning provisioning by others. I call for further research on adrenarche among the African apes as a critical comparison to humans. I also suggest research in subsistence populations to establish the role of nutrition and energetics in the timing of adrenarche and the onset of middle childhood.

Keywords: DHEAS; brain; growth and development; human evolution; middle childhood.

Figures

Figure 1
Figure 1
Hypothesized pathway linking meat consumption and neuronal activity. IGF-1 increases with the consumption of animal protein. Within the adrenal gland, IGF-1 prevents apoptosis of cells thus increasing the centripetal movement of cells from the Zona Glomerulus (ZG) and Zona Fascularis (ZF) into the Zona Reticularis (ZR). Increased IGF-1 would result in a thicker ZR and greater production of DHEA/S. DHEA/S crosses the blood brain barrier and enters into neurons. Within the neuron, DHEA acts at the Sigma-1 Receptor located on the mitochondrial associated membrane between the mitochondria and the endoplasmic reticulum. Activation of the Sigma-1 receptor acts to increase energy production and alleviate stress-related production of oxygen free radicals. The result is the increased production and release of neurotransmitters as suggested by the arrows along the axon.

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