The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

Azra Allahveisi; Fariba Seyedoshohadaei; Masomeh Rezaei; Narges Bazrafshan; Kaveh Rahimi

doi:10.1016/j.heliyon.2020.e03577

The effect of platelet-rich plasma on the achievement of pregnancy during frozen embryo transfer in women with a history of failed implantation

Heliyon. 2020 Mar 12;6(3):e03577. doi: 10.1016/j.heliyon.2020.e03577. eCollection 2020 Mar.

Authors

Azra Allahveisi^{1

2}, Fariba Seyedoshohadaei^{1

3}, Masomeh Rezaei^{1

3}, Narges Bazrafshan^{1

3}, Kaveh Rahimi^{1

4}

Affiliations

¹ Infertility Treatment Center of Besat Hospital, Kurdistan University of Medical Sciences, Sanandaj, Iran.
² Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
³ Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
⁴ Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Abstract

Objective: The aim of this study was to evaluate the effect of platelet-rich plasma (PRP) on the rate of implantation and pregnancy in women with repeated failed implantation during frozen embryo transfer.

Methods: This study was conducted on 50 infertile women candidates (who were referred to the Infertility Treatment Center of Besat Hospital in Sanandaj) with a history of failed implantation for the purpose of frozen embryo transfer. The participants were randomly divided into two groups (n = 25). In the first group (control), the intrauterine infusion of 0.5 ml of Ringer serum was done 48 h before embryo transfer. In the second group (treatment), the intrauterine infusion of 0.5 ml of PRP was performed 48 h before embryo transfer.

Results: In this study, there was no significant difference between the two groups in the rate of chemical and clinical pregnancy. The rate of chemical pregnancy was 28% in the treatment group and 36% in the control group, while the rate of clinical pregnancy was 28% in the treatment group and 24% in the control group.

Conclusion: The intrauterine infusion of PRP before frozen embryo transfer in infertile women with a history of failed implantation will not make any significant effect on the result of pregnancy.

Keywords: Clinical research; Frozen embryo transfer; Health sciences; Implantation; Obstetrics and gynecology; Pharmacology; Platelet-rich plasma; Pregnancy; Reproductive system; Women's health.