Effect of an Oral Nutrition Supplement Containing Collagen Peptides on Stratum Corneum Hydration and Skin Elasticity in Hospitalized Older Adults: A Multicenter Open-label Randomized Controlled Study

Adv Skin Wound Care. 2020 Apr;33(4):186-191. doi: 10.1097/01.ASW.0000655492.40898.55.


Objective: The purpose of this randomized open-label study was to investigate the effect of an oral nutrition supplement containing collagen peptides on stratum corneum hydration and skin elasticity.

Methods: The study protocol was registered at the UMIN Clinical Trials Registry (UMIN 000027347). Once-a-day oral administration of a nutrition supplement containing collagen peptides (10.0 g) was instituted in 39 inpatients 65 years or older who were assigned to either the intervention or the control group using a block-randomization design. Stratum corneum hydration and skin elasticity were measured at baseline and at 2, 4, 6, and 8 weeks after the start of the intervention.

Results: Mean stratum corneum hydration was significantly increased from 43.7 at baseline to 51.7 at postintervention week 8 in the intervention group (P = .001). Differences in skin elasticity from baseline were significant at postintervention week 6 (P = .026) and week 8 (P = .049).

Conclusions: Oral nutrition supplements containing collagen peptides may reduce skin vulnerability in older adults and thus prevent conditions such as skin tears.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Aged
  • Body Water / drug effects
  • Body Water / metabolism*
  • Collagen / therapeutic use*
  • Dietary Supplements*
  • Elasticity / drug effects
  • Epidermis / drug effects
  • Epidermis / metabolism*
  • Female
  • Humans
  • Hydrogen-Ion Concentration
  • Male
  • Skin / drug effects
  • Skin / metabolism*
  • Skin Physiological Phenomena


  • Collagen