Sex differences in redox homeostasis in renal disease

Tanecia Mitchell; Carmen De Miguel; Eman Y Gohar

doi:10.1016/j.redox.2020.101489

Sex differences in redox homeostasis in renal disease

Redox Biol. 2020 Apr:31:101489. doi: 10.1016/j.redox.2020.101489. Epub 2020 Mar 9.

Authors

Tanecia Mitchell¹, Carmen De Miguel², Eman Y Gohar³

Affiliations

¹ Department of Urology, University of Alabama at Birmingham, Birmingham, AL, USA.
² Section of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
³ Section of Cardio-Renal Physiology & Medicine, Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA. Electronic address: emangohar@uabmc.edu.

Abstract

Sex differences in redox signaling in the kidney present new challenges and opportunities for understanding the physiology and pathophysiology of the kidney. This review will focus on reactive oxygen species, immune-related signaling pathways and endothelin-1 as potential mediators of sex-differences in redox homeostasis in the kidney. Additionally, this review will highlight male-female differences in redox signaling in several major cardiovascular and renal disorders namely acute kidney injury, diabetic nephropathy, kidney stone disease and salt-sensitive hypertension. Furthermore, we will discuss the contribution of redox signaling in the pathogenesis of postmenopausal hypertension and preeclampsia.

Keywords: Endothelin-1; Inflammation; Kidney; ROS; Redox signaling; Sex-differences.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Female
Homeostasis
Humans
Kidney* / metabolism
Male
Oxidation-Reduction
Pregnancy
Reactive Oxygen Species / metabolism
Sex Characteristics*

Substances

Reactive Oxygen Species

Abstract

Publication types

MeSH terms

Substances

Grants and funding