99m Tc-labeled monosaccharide kits: development methods and quality control

Sci Rep. 2020 Mar 20;10(1):5121. doi: 10.1038/s41598-020-61707-7.


The paper presents the procedure for planning an experiment to create standard sets of reagents for a technetium-99m generator based on glucose derivatives. All stages are presented from researching the required quantities of a substance, a reducing agent, a stabilizer and auxiliary components to developing lyophilized kits and conducting quality control. The radiochemical purity of radiopharmaceuticals prepared on the basis of the developed kits ranged from 90.0 to 99.0%. We also showed the functional suitability of the developed preparations on C57B1/6j mice with an implanted malignant tumor - Lewis lung carcinoma.

Publication types

  • Research Support, Non-U.S. Gov't