Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report

Anna E DeNoble; Frances M Saccoccio; Sallie R Permar; Brenna L Hughes

doi:10.1093/cid/ciaa305

Prenatal Treatment of Congenital Cytomegalovirus With Valganciclovir: A Case Report

Clin Infect Dis. 2020 Dec 3;71(9):2506-2508. doi: 10.1093/cid/ciaa305.

Authors

Anna E DeNoble¹, Frances M Saccoccio², Sallie R Permar³, Brenna L Hughes¹

Affiliations

¹ Department of Obstetrics and Gynecology, Duke University, Durham, North Carolina, USA.
² Pediatric Infectious Diseases, University of Florida Shands Children's Hospital, Gainesville, Florida, USA.
³ Department of Pediatrics, Children's Health and Discovery Institute, Duke University, Durham, North Carolina, USA.

PMID: 32198512
DOI: 10.1093/cid/ciaa305

Abstract

Cytomegalovirus (CMV) is the most common congenital infection and infectious cause of fetal anomaly and neurologic injury. However, treatment strategies for congenital CMV (cCMV) infection during pregnancy remain elusive. We report a case of hydrops fetalis secondary to cCMV infection with minimal sequelae after maternal and subsequent neonatal treatment with valganciclovir.

Keywords: congenital infection; cytomegalovirus; intrauterine treatment; valganciclovir.

Publication types

Case Reports

MeSH terms

Cytomegalovirus
Cytomegalovirus Infections* / drug therapy
Female
Fetal Diseases* / drug therapy
Humans
Pregnancy
Pregnancy Complications, Infectious* / drug therapy
Valganciclovir / therapeutic use

Substances

Valganciclovir