Objectives: Few studies have reported that mood disorders increase the risk of benign paroxysmal positional vertigo (BPPV). The purpose of our study was to demonstrate whether the incidence of BPPV in those with mood disorders differs from that in a matched control group.
Study design: Nationwide cohort observational study.
Methods: Korean Health Insurance Review and Assessment Service-National Patient Samples were collected from 2002 to 2013. A 1:4 matched mood disorder group (n = 59,340) and control group (n = 237,720) were selected. The crude and adjusted (cerebral stroke, ischemic heart disease, anxiety disorder, and osteoporosis histories) hazard ratios (HRs) for depression and BPPV were analyzed using a stratified Cox proportional hazard model. The results were stratified by age, sex, income, region of residence, hypertension, diabetes, and dyslipidemia in these analyses.
Results: The incidence of BPPV was significantly higher in the mood disorder group than in the control group (3.2% vs. 2.1%, P < .001). Mood disorder increased the risk of BPPV (adjusted HR = 1.31, 95% confidence interval [CI] = 1.23-1.39, P < .001). In subgroup analyses, the incidence of BPPV in all age groups and in both sexes was significantly higher in the mood disorder group than in the control group.
Conclusion: This population-based cohort study demonstrates that mood disorder was significantly associated with BPPV.
Level of evidence: N/A. Laryngoscope, 2020.
Keywords: Mood disorder; benign paroxysmal positional vertigo; cohort study.
© 2020 The American Laryngological, Rhinological and Otological Society, Inc.
Osteoporosis increases the risk of benign paroxysmal positional vertigo: a nested case-control study using a national sample cohort.Eur Arch Otorhinolaryngol. 2019 Feb;276(2):335-342. doi: 10.1007/s00405-018-5230-y. Epub 2018 Dec 3. Eur Arch Otorhinolaryngol. 2019. PMID: 30511104
Association Between Migraine and Benign Paroxysmal Positional Vertigo Among Adults in South Korea.JAMA Otolaryngol Head Neck Surg. 2019 Apr 1;145(4):307-312. doi: 10.1001/jamaoto.2018.4016. JAMA Otolaryngol Head Neck Surg. 2019. PMID: 30676633 Free PMC article. Clinical Trial.
Increased Risk of Benign Paroxysmal Positional Vertigo in Patients With a History of Sudden Sensory Neural Hearing Loss: A Longitudinal Follow-up Study Using a National Sample Cohort.Otol Neurotol. 2019 Feb;40(2):e135-e141. doi: 10.1097/MAO.0000000000002084. Otol Neurotol. 2019. PMID: 30624405
Modifications of the Epley (canalith repositioning) manoeuvre for posterior canal benign paroxysmal positional vertigo (BPPV).Cochrane Database Syst Rev. 2012 Apr 18;2012(4):CD008675. doi: 10.1002/14651858.CD008675.pub2. Cochrane Database Syst Rev. 2012. PMID: 22513962 Free PMC article. Review.
Treatment and recurrence of traumatic versus idiopathic benign paroxysmal positional vertigo: a meta-analysis.Acta Otolaryngol. 2019 Sep;139(9):727-733. doi: 10.1080/00016489.2019.1632484. Epub 2019 Jul 3. Acta Otolaryngol. 2019. PMID: 31268396 Review.
- Trivedi MH, Morris DW, Wisniewski SR, et al. Clinical and sociodemographic characteristics associated with suicidal ideation in depressed outpatients. Can J Psychiatry 2013;58:113-122.
- Roy T, Lloyd CE. Epidemiology of depression and diabetes: a systematic review. J Affect Disord 2012;142:S8-S21.
- BaHammam AS, Kendzerska T, Gupta R, et al. Comorbid depression in obstructive sleep apnea: an under-recognized association. Sleep Breath 2016;20:447-456.
- Rudisch B, Nemeroff CB. Epidemiology of comorbid coronary artery disease and depression. Biol Psychiatry 2003;54:227-240.
- Katon WJ. Epidemiology and treatment of depression in patients with chronic medical illness. Dialogues Clin Neurosci 2011;13:7-23.