ImPlementation REsearCh to DEvelop Interventions for People Living with HIV (the PRECluDE consortium): Combatting chronic disease comorbidities in HIV populations through implementation research

Prog Cardiovasc Dis. Mar-Apr 2020;63(2):79-91. doi: 10.1016/j.pcad.2020.03.006. Epub 2020 Mar 19.


Antiretroviral therapy (ART) prevented premature mortality and improved the quality of life among people living with the human immunodeficiency virus (PLWH), such that now more than half of PLWH in the United States are 50 years of age and older. Increased longevity among PLWH has resulted in a significant rise in chronic, comorbid diseases. However, the implementation of guideline-based interventions for preventing, treating, and managing such age-related, chronic conditions among the HIV population is lacking. The PRECluDE consortium supported by the Center for Translation Research and Implementation Science at the National Heart, Lung, and Blood Institute catalyzes implementation research on proven-effective interventions for co-occurring heart, lung, blood, and sleep diseases and conditions among PLWH. These collaborative research studies use novel implementation frameworks with HIV, mental health, cardiovascular, and pulmonary care to advance comprehensive HIV and chronic disease healthcare in a variety of settings and among diverse populations.

Keywords: Antiretroviral therapy; COPD; Cardiovascular disease; Comorbidities; HIV; Implementation science.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-HIV Agents / adverse effects
  • Anti-HIV Agents / therapeutic use*
  • Antihypertensive Agents / therapeutic use
  • Chronic Disease
  • Comorbidity
  • Diffusion of Innovation
  • Female
  • HIV Infections / diagnosis
  • HIV Infections / drug therapy*
  • HIV Infections / epidemiology
  • HIV Infections / virology
  • HIV Long-Term Survivors*
  • Health Behavior
  • Health Status
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Implementation Science*
  • Male
  • Middle Aged
  • Noncommunicable Diseases / epidemiology
  • Noncommunicable Diseases / prevention & control*
  • Preventive Health Services*
  • Protective Factors
  • Respiratory Therapy
  • Risk Assessment
  • Risk Factors
  • Risk Reduction Behavior
  • Translational Medical Research*
  • Viral Load
  • Young Adult


  • Anti-HIV Agents
  • Antihypertensive Agents
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors