Not all HLA epitope mismatches are equal

Sebastiaan Heidt; Frans H J Claas

doi:10.1016/j.kint.2019.12.017

Not all HLA epitope mismatches are equal

Kidney Int. 2020 Apr;97(4):653-655. doi: 10.1016/j.kint.2019.12.017.

Authors

Sebastiaan Heidt¹, Frans H J Claas²

Affiliations

¹ Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: S.Heidt@lumc.nl.
² Eurotransplant Reference Laboratory, Leiden University Medical Center, Leiden, the Netherlands.

PMID: 32200859
DOI: 10.1016/j.kint.2019.12.017

Abstract

The future of HLA matching in solid organ transplantation lies in epitope matching. The article by Sapir-Pichhadze et al. provides indirect evidence that there is a difference in immunogenicity between antibody-verified versus non-verified eplets. However, this difference was less clear for HLA class II, showing the need for additional efforts to identify truly immunogenic HLA class II epitope mismatches.

Publication types

Comment

MeSH terms

Antibodies
Epitopes
Histocompatibility Testing
Kidney Transplantation*
Organ Transplantation*

Substances

Antibodies
Epitopes