RIG-I-like receptors: their regulation and roles in RNA sensing

Nat Rev Immunol. 2020 Sep;20(9):537-551. doi: 10.1038/s41577-020-0288-3. Epub 2020 Mar 13.


Retinoic acid-inducible gene I (RIG-I)-like receptors (RLRs) are key sensors of virus infection, mediating the transcriptional induction of type I interferons and other genes that collectively establish an antiviral host response. Recent studies have revealed that both viral and host-derived RNAs can trigger RLR activation; this can lead to an effective antiviral response but also immunopathology if RLR activities are uncontrolled. In this Review, we discuss recent advances in our understanding of the types of RNA sensed by RLRs in the contexts of viral infection, malignancies and autoimmune diseases. We further describe how the activity of RLRs is controlled by host regulatory mechanisms, including RLR-interacting proteins, post-translational modifications and non-coding RNAs. Finally, we discuss key outstanding questions in the RLR field, including how our knowledge of RLR biology could be translated into new therapeutics.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • DEAD Box Protein 58 / physiology*
  • Humans
  • Immune System / physiology
  • RNA / metabolism*
  • RNA, Viral / metabolism


  • RNA, Viral
  • RNA
  • DEAD Box Protein 58