Is aggressive intravenous fluid resuscitation beneficial in acute pancreatitis? A meta-analysis of randomized control trials and cohort studies

World J Gastroenterol. 2020 Mar 14;26(10):1098-1106. doi: 10.3748/wjg.v26.i10.1098.


Background: There is conflincting evidence on the intravenous fluid (IVF) strategy for acute pancreatitis (AP). We perform a metaanalysis of the available evidence.

Aim: To investigate if aggressive IVF therapy in AP patients is beneficial to decrease mortality and improve outcomes.

Methods: Metaanalysis of available randomized controlled trials and cohort studies comparing aggressive IVF vs non-aggressive IVF resuscitation.

Results: There was no significant difference in mortality between the aggressive (n = 1229) and non-aggressive IVF (n = 1397) patients. Patients receiving aggressive IVF therapy had higher risk for acute kidney injury and acute respiratory distress syndrome. There also was no significant difference in the overall incidence of systemic inflammatory response syndrome, persistent organ failure, pancreatic necrosis when comparing both study groups.

Conclusion: Early aggressive IVF therapy did not improve mortality. Moreover, aggressive IVF therapy could potentially increase the risk for acute kidney injury and pulmonary edema leading to respiratory failure and mechanical ventilation. Studies are needed to investigate which subset of AP patients could benefit from aggressive IVF therapy.

Keywords: Acute pancreatitis; Aggressive fluid resuscitation; Intravenous fluid resuscitation.

Publication types

  • Meta-Analysis
  • Review

MeSH terms

  • Acute Disease
  • Acute Kidney Injury / etiology
  • Acute Kidney Injury / mortality
  • Administration, Intravenous
  • Cohort Studies
  • Fluid Therapy / methods
  • Fluid Therapy / mortality*
  • Humans
  • Incidence
  • Pancreatitis / mortality*
  • Pancreatitis / therapy*
  • Pancreatitis, Acute Necrotizing / etiology
  • Pancreatitis, Acute Necrotizing / mortality
  • Pulmonary Edema / etiology
  • Pulmonary Edema / mortality
  • Randomized Controlled Trials as Topic
  • Resuscitation / methods
  • Resuscitation / mortality*
  • Systemic Inflammatory Response Syndrome / etiology
  • Systemic Inflammatory Response Syndrome / mortality*
  • Treatment Outcome