The frequency of vitamin D deficiency in chronic kidney disease and its relation with baseline mineral bone markers

J Pak Med Assoc. 2020 Mar;70(3):432-436. doi: 10.5455/JPMA.302411.


Objective: To assess the frequency of Vitamin D deficiency in chronic kidney disease and its association with baseline mineral bone markers in patients visiting nephrology clinics.

Methods: The observational study was conducted at the Indus Hospital, Karachi, from January 2017 to January 2018, and comprised patients of either gender aged >16 years diagnosed with chronic kidney disease stage I-V. The patients were divided into two groups on the basis of severity of vitamin D deficiency. Severe vitamin D deficiency was defined as <10ng/ml, and moderate deficiency ad 10- 25ng/ml. Data was analysed using SPSS 21.

Results: Of the 267 patients, 146(54.7%) were males and 189(70.8%) had vitamin D deficiency. Vitamin D-deficient patients were younger than those with normal levels (p=0.044). Serum creatinine was raised in the deficient patients compared to those with normal vitamin D level (p=0.042). Females and currently employed patients were at a higher risk of having vitamin D deficiency (p=0.048, 0.009). There was no si gn ific ant as s ociation between disease stage a nd vitamin D defic ienc y ( p= 0.311).

Conclusions: Vitamin D deficiency was found in a significant proportion of chronic kidney disease patients irrespective of the disease stage. Females, currently employed and young patients were more prone to having vitamin D deficiency.

Keywords: CKD, Vitamin D deficiency, Mineral bone markers..

Publication types

  • Observational Study

MeSH terms

  • Adult
  • Age Factors
  • Bone Density
  • Correlation of Data
  • Employment
  • Female
  • Humans
  • Male
  • Pakistan / epidemiology
  • Renal Insufficiency, Chronic* / blood
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / epidemiology
  • Risk Factors
  • Severity of Illness Index
  • Sex Factors
  • Vitamin D / blood*
  • Vitamin D Deficiency* / blood
  • Vitamin D Deficiency* / diagnosis
  • Vitamin D Deficiency* / epidemiology


  • Vitamin D